Human antibody responses to Brugia malayi antigens in brugian filariasis.
Int J Parasitol
; 29(3): 429-36, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10333326
ABSTRACT
Human antibody responses to Brugia malayi antigens were studied with sera from a Brugia endemic area in South India. Patients with clinical filariasis had significantly higher IgE and lower IgG4 levels to adult worm antigens than people with asymptomatic microfilaraemia. Intermediate antibody levels were observed in endemic normals. A majority of sera from each clinical group contained IgG antibodies to surface antigens of infective larvae (L3) by IFAT. IgG immunoblot studies did not reveal group differences in L3 antigen recognition. IgE antibodies bound to a subset of antigens bound by IgG. IgE antibodies in sera from clinical filariasis patients preferentially bound to L3 antigens at 200, 97, 68 and 58 kDa compared with sera from microfilaria carriers. These results are consistent with prior studies of antibody responses in filariasis and add new information on the targets of IgG and IgE antibodies to L3 antigens in brugian filariasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filariose Linfática
/
Anticorpos Anti-Helmínticos
/
Brugia Malayi
/
Antígenos de Helmintos
Limite:
Adult
/
Animals
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Parasitol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos