Relation of genetic polymorphisms of apolipoprotein E, angiotensin converting enzyme, apolipoprotein B-100, and glycoprotein IIIa and early-onset coronary heart disease.
Clin Biochem
; 32(4): 275-82, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10463820
ABSTRACT
OBJECTIVE:
Apolipoprotein E (APOE) E4, apolipoprotein B-100 (APOB) Q3611 allele, the angiotensin converting enzyme (ACE) deletion (D) allele and glycoprotein IIIa (GP3A) P33 mutant allele are reported to predispose to early-onset coronary heart disease (CHD). These associations were not all confirmed in more recent studies. To determine the impact of these alleles on CHD, we examined the prevalence of these mutations in patients presenting with early-onset CHD and compared them to those manifesting CHD later in life. The delayed-onset was considered a sign of longevity and would serve as a comparative group to assess prevalence of the biochemical and genetic risk factors.METHODS:
300 patients with a history of myocardial infarction or angina pectoris and angiographically documented CHD were studied. Patients were divided into two groups group 1 (G1 = 150 patients) presenting with these findings under the age of 50 years; while group 2 (G2 = 150 patients) were patients presenting for the first time over the age of 65 years. Prevalence of the alleles of APOE, APOB, ACE and GP3A was assessed by molecular analysis. An association of any of these genotypes with early onset CHD could lead to a higher prevalence in the younger age group. RESULTS ANDCONCLUSIONS:
None of the suspected alleles namely APOB Q3611 [G1 10.7% vs. G2 9.0%, p = 0.57], ACE D (G1 52.0% vs. G2 49.7%, p = 0.57), or the GP3A P33 (G1 17.3% vs. G2 15.7%; p = 0.58) showed any significant difference between the two groups. Subjects with APOE E4 were more frequent in the younger age group (G1 18.3% vs. G2 13.7%; p = 0.047), while APOE E2 was more frequent in G2 (G2 10.0% vs. G1 2.7%; p = 0.0002). Multivariate analysis showed an odds ratio of APOE E2 allele in G1 of 0.27 with a confidence interval of 0.10-0.73.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas B
/
Apolipoproteínas E
/
Polimorfismo Genético
/
Peptidil Dipeptidase A
/
Complexo Glicoproteico GPIIb-IIIa de Plaquetas
/
Doença das Coronárias
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Canadá