Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse.
Nat Med
; 5(10): 1183-7, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10502823
ABSTRACT
Retinitis pigmentosa is an inherited degenerative disease of photoreceptors leading to blindness. A well-characterized model for this disease is provided by the retinal degeneration mouse, in which the gene for the rod cGMP phosphodiesterase is mutated, as in some affected human families. We report that D-cis-diltiazem, a calcium-channel blocker that also acts at light-sensitive cGMP-gated channels, rescued photoreceptors and preserved visual function in the retinal degeneration mouse. The long record of diltiazem prescription in cardiology should facilitate the design of clinical trials for some forms of retinitis pigmentosa.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Diltiazem
/
Retinose Pigmentar
/
Células Fotorreceptoras Retinianas Bastonetes
/
Fármacos Neuroprotetores
Limite:
Animals
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
França