Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.
Science
; 286(5449): 2531-4, 1999 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-10617474
ABSTRACT
Mice lacking mCry1 and mCry2 are behaviorally arrhythmic. As shown here, cyclic expression of the clock genes mPer1 and mPer2 (mammalian Period genes 1 and 2) in the suprachiasmatic nucleus and peripheral tissues is abolished and mPer1 and mPer2 mRNA levels are constitutively high. These findings indicate that the biological clock is eliminated in the absence of both mCRY1 and mCRY2 (mammalian cryptochromes 1 and 2) and support the idea that mammalian CRY proteins act in the negative limb of the circadian feedback loop. The mCry double-mutant mice retain the ability to have mPer1 and mPer2 expression induced by a brief light stimulus known to phase-shift the biological clock in wild-type animals. Thus, mCRY1 and mCRY2 are dispensable for light-induced phase shifting of the biological clock.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relógios Biológicos
/
Proteínas Nucleares
/
Ritmo Circadiano
/
Células Fotorreceptoras de Invertebrados
/
Proteínas de Drosophila
/
Proteínas do Olho
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Flavoproteínas
/
Luz
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão