Reduced expression of p27(Kip1) correlates with an early stage of cancer invasion in oral squamous cell carcinoma.
Cancer Lett
; 151(2): 217-22, 2000 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-10738117
ABSTRACT
Down-regulation of p27(Kip1) has been reported to correlate with poor survival of various carcinoma patients including oral squamous cell carcinomas (OSCCs). It is still unclear, however, at what stage of oral carcinogenesis the down-regulation of this protein occurs. In this study, therefore, we evaluated immunoexpression of p27(Kip1) protein in 17 cases of oral epithelial dysplasia and succeeding invasive OSCC in the same patient. We reported here that 88% cases showed high p27(Kip1) expression in dysplastic lesions, whereas 82% cases of succeeding invasive OSCC exhibited reduced expression. The reduction of p27(Kip1) expression was also observed in 16 of 19 (84%) early invasive lesions and well correlated with Ki-67 expression which is good indicator of cell proliferation. We also investigated immunoexpression of p53 protein of which abnormality has been known to occur during the early stage of OSCC development. Overexpression of p53 protein was demonstrated in 29% of dysplastic lesions, 42% of early invasive and 71% of invasive OSCCs. These findings suggest that abnormalities of both p53 and p27(Kip1) are involved in the carcinogenesis of OSCC, but they seem to play their role at different stages of oral cancer development, respectively. Reduced expression of p27(Kip1) may concern the cancer invasion directly or indirectly as well as abnormal proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Proteínas de Ciclo Celular
/
Proteínas Supressoras de Tumor
/
Proteínas Associadas aos Microtúbulos
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão