Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures.
Biochem J
; 348 Pt 2: 433-8, 2000 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-10816439
ABSTRACT
Insulin stimulates glucose utilization in the liver, which occurs mainly in the less aerobic, perivenous, zone. Accordingly, the insulin receptor protein was predominantly expressed in this area, although the insulin receptor mRNA was homogeneously distributed. In hepatocyte cultures venous O(2) partial pressure (pO(2)) induced insulin receptor protein expression. High glucose concentrations enhanced insulin receptor protein under arterial and venous pO(2). The induction of insulin receptor protein by venous pO(2) would explain its zonated expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Receptor de Insulina
/
Regulação da Expressão Gênica
/
Glucose
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Biochem J
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha