Enantioselective automultiplication of chiral molecules by asymmetric autocatalysis.
Acc Chem Res
; 33(6): 382-90, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10891056
ABSTRACT
Asymmetric autocatalysis is a process of automultiplication of a chiral compound in which chiral product acts as a chiral catalyst for its own production. The discovery and the development of asymmetric autocatalysis of pyrimidyl-, quinolyl-, and pyridylalkanols are described in the enantioselective additions of diisopropylzinc to the corresponding nitrogen-containing aldehydes. (Alkynylpyrimidyl)alkanols automultiply with a yield of over 99% and over 99.5% ee. Asymmetric autocatalysts with extremely low ee's automultiply with significant amplification of ee's without the need for any other chiral auxiliaries. Small enantiomeric imbalances of chiral molecules induced by physical factors can be amplified by the present asymmetric autocatalysis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Álcoois
/
Aminoácidos
Idioma:
En
Revista:
Acc Chem Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão