Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila.
Proc Natl Acad Sci U S A
; 97(21): 11427-32, 2000 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-11027343
ABSTRACT
We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/alpha(2)-macroglobulin superfamily. The genes are transcribed at a low level during all stages of development, and their expression is markedly up-regulated after an immune challenge. For one of these genes, which is predominantly expressed in the larval fat body, we observe a constitutive expression in gain-of-function mutants of the Janus kinase (JAK) hop and a reduced inducibility in loss-of-function hop mutants. We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Glicoproteínas de Membrana
/
Proteínas
/
Receptores de Superfície Celular
/
Proteínas de Insetos
/
Proteínas de Drosophila
/
Drosophila
/
Mutação
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França