The effect of estrogen replacement therapy on cardiac autonomic regulation.
Maturitas
; 37(1): 45-51, 2000 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-11099873
ABSTRACT
OBJECTIVE:
To study the effects of estrogen replacement therapy (ERT) and sleep stage on autonomic cardiac regulation. SRUDYDESIGN:
Seventy-one healthy postmenopausal women received transdermal ERT and placebo separated by a washout in a randomized, placebo-controlled, double-blind, cross-over trial. Polysomnography was conducted at the end of each treatment. Heart rate variability (HRV) was assessed in epochs of the awake state, stage 2, slow wave and REM sleep. The effects of estradiol and sleep stages on HRV were analyzed.RESULTS:
ERT decreased heart rate in the awake state and quiet sleep, but not in REM sleep. ERT did not change the heart rate variability. Heart rate decreased and HRV increased during stage 2 and slow wave sleep compared with the awake state with placebo. In REM sleep, similarly, heart rate increased above awake values and the values of HRV parameters fell back to awake levels.CONCLUSIONS:
The results suggest that ERT increases vagal tone, but does not change cardiac vagal modulation. Changes in HRV suggest a strong vagal influence in non-REM and a sympathetic influence in REM sleep.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Terapia de Reposição de Estrogênios
/
Pós-Menopausa
/
Estradiol
/
Frequência Cardíaca
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Maturitas
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Finlândia