Ser186Pro mutation of RHO gene in a Spanish autosomal dominant retinitis pigmentosa (ADRP) family.
Ophthalmic Genet
; 21(4): 251-6, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11135497
ABSTRACT
A Spanish family affected with autosomal dominant retinitis pigmentosa (ADRP) with a diffuse phenotype showed a mutation in the rhodopsin gene. The mutation was the transition T-->C in codon 186, which has been reported once before in an American patient (Dryja et al., Proc Natl Acad Sci USA 1991;889370-9374). This change replaces a serine by a proline in the second intradiscal loop of the protein, generating a molecule that is probably folding- and transport-defective.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rodopsina
/
Retinose Pigmentar
/
Mutação Puntual
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ophthalmic Genet
Assunto da revista:
GENETICA MEDICA
/
OFTALMOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Espanha