Drug-targeting strategies in cancer therapy.
Curr Opin Genet Dev
; 11(1): 104-10, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11163159
ABSTRACT
Genetic changes in cell-cycle, apoptotic, and survival pathways cause tumorigenesis, leading to significant phenotypic changes in transformed cells. These changes in the tumor environment - elevated expression of surface proteases, increased angiogenesis and glucuronidase activity - can be taken advantage of to improve the therapeutic index of existing cancer therapies. Targeting cytotoxics to tumor cells by enzymatic activation is a promising strategy for improving chemotherapeutics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pró-Fármacos
/
Sistemas de Liberação de Medicamentos
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos