Prognostic and therapeutic implications of sentinel lymphonodectomy and S-staging in Merkel cell carcinoma.
Dermatology
; 202(3): 225-9, 2001.
Article
em En
| MEDLINE
| ID: mdl-11385228
ABSTRACT
BACKGROUND:
Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine neoplasm of the skin with a high propensity for early lymph node metastasis and subsequent distant spread. Optimal treatment and prognostic factors are poorly defined.OBJECTIVE:
The purpose of this study is to assess the prognostic and therapeutic relevance of sentinel lymphonodectomy in MCC.METHODS:
Five patients with biopsy-proven MCC underwent gamma-probe-guided sentinel lymphonodectomy assisted by lymphatic mapping. From each sentinel lymph node (SLN), a series of paraffin sections was histologically and immunohistochemically examined for the presence of micrometastases, which were then staged according to the recently published S classification.RESULTS:
Four of the 5 patients showed metastatic disease in the SLNs, 3 of which were classified as S(2), 1 as S(3). Only 1 of the S(2) patients demonstrated additional positive nodes at completion lymphonodectomy. The patient staged as S(3) refused a radical lymph node dissection and died within 1 year due to widespread metastasis.CONCLUSIONS:
Sentinel lymphonodectomy is a low-morbidity procedure which enables an early detection and exact staging of regional lymph node metastases with potentially high prognostic and therapeutic relevance in MCC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Célula de Merkel
/
Biópsia de Linfonodo Sentinela
/
Metástase Linfática
Tipo de estudo:
Prognostic_studies
/
Screening_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dermatology
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha