Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells.
Life Sci
; 68(12): 1449-55, 2001 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-11388696
ABSTRACT
Whether the diurnal rhythm of cell cycle is associated with that of interferon-alpha/beta receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-alpha to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-beta. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Ritmo Circadiano
/
Receptores de Interferon
/
Melanoma
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão