Increased level of cholecystokinin in cerebrospinal fluid is associated with chronic pain-like behavior in spinally injured rats.
Peptides
; 22(8): 1305-8, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11457525
ABSTRACT
Cholecystokinin (CCK) is a physiological antagonist of opioid-mediated antinociception and may be involved in some chronic pain states where opioids have reduced effect. We have previously shown in a rat model of central neuropathic pain after spinal cord injury that blockade of CCK-B receptors lead to marked pain relief. In the present study, we showed that spinally injured rats exhibiting chronic pain-like behaviors (aversive reaction to innocuous mechanical and cold stimulation) had significantly elevated level of CCK-like immunoreactivity in cerebrospinal fluid compared to normal rats or spinally injured rats which did not exhibit pain-like behaviors. The increased level of circulating CCK in the cerebrospinal fluid may thus contribute to the maintenance of chronic pain in these rats by reducing the endogenous inhibitory tone provided by opioid peptides and may be involved in the phenomenon of opioid insensitivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Traumatismos da Medula Espinal
/
Comportamento Animal
/
Colecistocinina
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Suécia