Mice lacking histidine decarboxylase exhibit abnormal mast cells.
FEBS Lett
; 502(1-2): 53-6, 2001 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-11478947
ABSTRACT
Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histidina Descarboxilase
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão