Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. 9. N-Heterocyclic acraldoximes methiodides.
J Med Chem
; 18(8): 839-42, 1975 Aug.
Article
em En
| MEDLINE
| ID: mdl-1159702
ABSTRACT
N-Heterocyclic acraldoximes methiodides, where the heterocyclic residues are 2-, 3-, and 4-pyridyl, 2-(1-methyl)imidazolyl or 4-pyrimidyl, were prepared and tested for their reactivating potency on acetylcholinesterase inhibited from diisopropylphosphorofluoridate (DFP). The in vitro testing revealed that the new compounds are good reactivators of the phosphorylated electric eel cholinesterase. The structure-activity relationships are briefly discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Acroleína
/
Inibidores da Colinesterase
/
Reativadores da Colinesterase
/
Aldeídos
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1975
Tipo de documento:
Article