In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells.
Cancer Lett
; 174(1): 17-24, 2001 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-11675148
ABSTRACT
The root of Paeonia suffruticosa ANDREWS is an important Chinese crude drug used in many traditional prescriptions. 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a major component of this crude drug, was found to exhibit in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. The growth-inhibitory effect was related to the ability of PGG not only to cause a G(0)/G(1) phase arrest but also to suppress the activation of nuclear factor-kappa B. Neither apoptosis nor necrosis was observed in the cells treated with PGG. These findings suggest that PGG could be a candidate for developing a low-toxic anticancer agent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taninos
/
Carcinoma Hepatocelular
/
Taninos Hidrolisáveis
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Coréia do Sul