Interaction of lyssaviruses with the low-affinity nerve-growth factor receptor p75NTR.
J Gen Virol
; 82(Pt 12): 2861-2867, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11714960
ABSTRACT
The low-affinity nerve-growth factor receptor p75NTR interacts in vitro with the rabies virus (RV) glycoprotein and serves as a receptor for RV. The Lyssavirus genus comprises seven genotypes (GTs) of rabies and rabies-related viruses. The ability of p75NTR to interact with the glycoprotein of representative lyssaviruses from each GT was investigated. This investigation was based on a specific binding assay between BSR cells infected with a lyssavirus and Spodoptera frugiperda (Sf21) cells expressing p75NTR on the cell surface. A specific interaction was observed with the glycoprotein of GT 1 RV (challenge virus standard or Pasteur virus strains) as well as wild-type RV and the glycoprotein of GT 6 European bat lyssavirus type 2. In contrast, no interaction was detected with the glycoprotein of lyssaviruses of GTs 2-5 and 7. Therefore, p75NTR is only a receptor for some lyssavirus glycoproteins, indicating that the other GTs must use an alternative specific receptor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Receptores de Fator de Crescimento Neural
/
Vírus Lassa
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2001
Tipo de documento:
Article