Gene expression profiling of aging using DNA microarrays.
Mech Ageing Dev
; 123(2-3): 177-93, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11718811
ABSTRACT
We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Expressão Gênica
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos