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Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer.
Wu, Y Q; Chen, H; Rubin, M A; Wojno, K J; Cooney, K A.
Afiliação
  • Wu YQ; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0946, USA.
Cancer Res ; 61(24): 8651-3, 2001 Dec 15.
Article em En | MEDLINE | ID: mdl-11751379
ABSTRACT
The recognition that prostate cancer clusters within families has led to the search for prostate cancer susceptibility genes. Recently, the HPC2/ELAC2 gene on chromosome 17p has been identified as a potential prostate cancer predisposition gene using both family based as well as case-control studies. Many cancer susceptibility genes act as tumor suppressor genes in which inactivation of one allele in the tumor can be detected via loss of heterozygosity (LOH). To determine whether the HPC2/ELAC2 gene demonstrates significant LOH in sporadic and familial prostate cancers, paired tumor and normal DNA samples were isolated using microdissection techniques from 44 radical prostatectomy specimens. Cases were analyzed using a panel of markers in the following order TP53-D17S969-D17S947-(HPC2/ELAC2)-D17S799-D17S936. LOH was observed in < 10% of cases using the four markers that map to the HPC2/ELAC2 region. However, allelic loss was observed at the TP53 gene in 25% of informative cases. Taken together, inactivation of the HPC2/ELAC2 gene via LOH is a relatively uncommon event in prostate cancer. Future studies will determine whether 17p LOH occurs in the subset of patients with an inherited mutation in HPC2/ELAC2.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Perda de Heterozigosidade / Proteínas de Neoplasias Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Perda de Heterozigosidade / Proteínas de Neoplasias Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Estados Unidos