Bacteriopurpurinimides: highly stable and potent photosensitizers for photodynamic therapy.
J Med Chem
; 45(2): 255-8, 2002 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-11784129
ABSTRACT
The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of (3)H-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.
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Base de dados:
MEDLINE
Assunto principal:
Porfirinas
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Fármacos Fotossensibilizantes
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article