Quantitative linkage: a statistical procedure for its detection and estimation.
Ann Hum Genet
; 38(4): 439-49, 1975 May.
Article
em En
| MEDLINE
| ID: mdl-1190735
ABSTRACT
A new approach for detecting and estimating quantitative linkage which uses sibship data is presented. Using a nested analysis of variance design (with marker genotype nested within sibship), it is shown that under the null hypothesis of no linkage, the expected between marker genotype within sibship mean square (EMSbeta) is equal to the expected within marker genotype within sibship mean square (EMSe), while under the alternative hypothesis of linkage, the first is greater than the second. Thus the regular F-ratio, MSbeta/MSe, can be used to test for quantitative linkage. This is true for both backcross and intercross matings and whether or not there is dominance at the marker locus. A second test involving the comparison of the within marker genotype within sibship variances is available for intercross matings. A maximum likelihood procedure for the estimation for the recombination frequency is also presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ligação Genética
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Hum Genet
Ano de publicação:
1975
Tipo de documento:
Article