Computational cell biology: spatiotemporal simulation of cellular events.
Annu Rev Biophys Biomol Struct
; 31: 423-41, 2002.
Article
em En
| MEDLINE
| ID: mdl-11988477
ABSTRACT
The field of computational cell biology has emerged within the past 5 years because of the need to apply disciplined computational approaches to build and test complex hypotheses on the interacting structural, physical, and chemical features that underlie intracellular processes. To meet this need, newly developed software tools allow cell biologists and biophysicists to build models and generate simulations from them. The construction of general-purpose computational approaches is especially challenging if the spatial complexity of cellular systems is to be explicitly treated. This review surveys some of the existing efforts in this field with special emphasis on a system being developed in the authors' laboratory, Virtual Cell. The theories behind both stochastic and deterministic simulations are discussed. Examples of respective applications to cell biological problems in RNA trafficking and neuronal calcium dynamics are provided to illustrate these ideas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biofísica
/
Técnicas Citológicas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biophys Biomol Struct
Assunto da revista:
BIOFISICA
/
BIOLOGIA MOLECULAR
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos