Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.
Bioorg Med Chem Lett
; 12(13): 1751-4, 2002 Jul 08.
Article
em En
| MEDLINE
| ID: mdl-12067553
ABSTRACT
A series of new, diene-modified nodulisporic acid analogues (2) bearing diverse functionality at the 3"- and 4"-sites was efficiently prepared from the 3"-aldehyde 3. Biological evaluation of these synthetic nodulisporic acid analogues for systemic flea efficacy identified potent compounds and further clarified the structural requirements for ectoparasite activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indóis
/
Inseticidas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos