Efficacy of porcine secretin in children with autism and pervasive developmental disorder.
J Autism Dev Disord
; 32(3): 153-60, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12108616
ABSTRACT
Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Autístico
/
Secretina
/
Transtornos Globais do Desenvolvimento Infantil
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Autism Dev Disord
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos