N-Cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.
Bioorg Med Chem Lett
; 12(17): 2475-8, 2002 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-12161161
ABSTRACT
A systematic structure-activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]-L-phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The data are consistent with a model of these compounds in which these alkanoylphenylalanines reside in a compact gauche (-) bioactive conformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Molécula 1 de Adesão de Célula Vascular
/
Integrina alfa4beta1
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos