XY female with a dysgerminoma and no mutation in the coding sequence of the SRY gene.
Cancer Genet Cytogenet
; 136(1): 58-61, 2002 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-12165453
ABSTRACT
We report a 46,XY 11-year-old girl with pure gonadal dysgenesis who developed a dysgerminoma. The testis-determining gene SRY, a candidate for sex reversal, whose alterations seem to correlate with dysgerminoma, was analyzed and found to be normal; its coding sequence was negative for deletions and mutations. DMRT-1 gene mapping on 9p and DAX-1 on Xp21 were also normal. These results suggest the involvement of other genes in sex reversal and call into question the putative relationship between SRY alterations and dysgerminoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Fatores de Transcrição
/
Proteínas Nucleares
/
Proteínas de Ligação a DNA
/
Disgerminoma
Limite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália