[Immunoglobulins and staphylococcal antitoxin in the sera of patients subjected to surgery for acute appendicitis]. / Immunoglobuliny i stafilokokkovoi antitoksin v syvorotkakh bol'nykh, operirovannykh po povodu ostrogo appenditsita

ABSTRACT

The content of staphylococcus antitoxin and IgA, IgG and IgM was studied in the sera of 200 patients operated on for various forms of acute appendicitis. 147 patients were subjected to express-immunization with a crude staphylococcus toxoid. It was revealed that the IgA, IgG and IgM level was much lower in the operated on patients than in healthy persons. Express immunization with the toxoid led to a marked increase in the level of staphylococcus antitoxin and also of the IgA, IgG, IgM in the sera of the vaccinated persons. There was no distinct association between the immunoglobulin content in the sera of the patients and the appearance in them of postoperative complications of staphylococcus etiology; it is not excluded, however, that an intensified IgM synthesis could play a certain role in the protection of the macroorganism from staphylococcus infection. A moderate, but statistically significant correlation between the titre of the staphylococcus antitoxin in the sera of the patients and the content of the IgM and IgA in them was revealed.