Human antibody response to Toscana virus glycoproteins expressed by recombinant baculovirus.
J Med Virol
; 68(4): 615-9, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12376972
ABSTRACT
The arthropod-borne Toscana virus has been associated with acute neurological disease in humans. In this study, the viral envelope glycoproteins were expressed in soluble form in a baculovirus system. The recombinant sGN and sGC proteins were used as viral antigens in a Western blot assay to analyze the specific immune response in sera from patients with recognized virus-associated aseptic meningitis. The anti-glycoprotein and the anti-nucleoprotein N IgG responses were compared by an immunoassay based on the recombinant proteins. In this system, all the sera showed a high reactivity to the N protein, but they differed in the response to the glycoproteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais de Fusão
/
Febre por Flebótomos
/
Vírus da Febre do Flebótomo Napolitano
/
Anticorpos Antivirais
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália