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[Growth hormone deficiency in the adult: only an endocrinologic problem?]. / Il deficit di ormone della crescita nell'adulto: un problema solo endocrinologico?
Martini, Chiara; Maffei, Pietro; De Carlo, Eugenio; Mioni, Roberto; Sicolo, Nicola; Scandellari, Cesare.
Afiliação
  • Martini C; Clinica Medica III, Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Padova. martinichiara@libero.it
Ann Ital Med Int ; 17(3): 149-56, 2002.
Article em It | MEDLINE | ID: mdl-12402662
In the literature published during the last decade an increased risk of death due to cerebrovascular and cardiovascular events in growth hormone deficient adults has been reported. A partial reversibility of the syndrome following recombinant growth hormone treatment has also been described. Both these factors have contributed to the proposal of growth hormone therapy not only for children but also for adults. Following the initial enthusiasm, the scientific community is now evaluating various clinical experiences held over recent years and weighing up the results. Present day medicine has to take the economic impact of prescribed therapeutic regimens into consideration; in other words the ratio between cost and benefits must be calculated. The relatively recent issuance of the license for the treatment of growth hormone deficiency in adults using recombinant growth hormone does not allow us to evaluate a possible reduction in the risk of death due to cerebrovascular and cardiovascular events in treated subjects. A much longer observational period will be required. Besides the partial reversibility of the syndrome as a consequence of treatment, it is necessary to single out the selection criteria for the choice of treatment. These could also be useful as indicators of the efficacy of the same treatment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio do Crescimento Humano Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: It Revista: Ann Ital Med Int Assunto da revista: MEDICINA INTERNA Ano de publicação: 2002 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio do Crescimento Humano Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: It Revista: Ann Ital Med Int Assunto da revista: MEDICINA INTERNA Ano de publicação: 2002 Tipo de documento: Article