[A molecular epidemiological study of childhood lead poisoning in lead-polluted environment].
Zhonghua Liu Xing Bing Xue Za Zhi
; 23(3): 175-8, 2002 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-12411083
ABSTRACT
OBJECTIVE:
The relationship between polymorphisms of ALAD and VDR genes and individual susceptibility of lead poisoning was investigated in children highly-exposed to lead.METHOD:
Four hundred and sixty-nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the methods of PCR-RFLP.RESULTS:
The subjects with ALAD2 allele had higher ZPP level (10.12 micro mol/L vs 12.87 micro mol/L) (P = 0.017). The subjects with B allele has larger head circumference than only with b allele (51.19 cm vs 50.75 cm) (P = 0.028).CONCLUSIONS:
It was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead-polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifying the susceptibility of lead poisoning.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluição Ambiental
/
Chumbo
/
Intoxicação por Chumbo
Tipo de estudo:
Etiology_studies
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Liu Xing Bing Xue Za Zhi
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
China