Regulatory mechanisms that govern nicotinic synapse formation in neurons.
J Neurobiol
; 53(4): 542-55, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12436419
ABSTRACT
Individual cholinoceptive neurons express high levels of different neuronal nicotinic acetylcholine receptor (nAChR) subtypes, and target them to the appropriate synaptic regions for proper function. This review focuses on the intercellular and intracellular processes that regulate nAChR expression in vertebrate peripheral nervous system (PNS) and central nervous system (CNS) neurons. Specifically, we discuss the cellular and molecular mechanisms that govern the induction and maintenance of nAChR expression-innervation, target tissue interactions, soluble factors, and activity. We define the regulatory principles of interneuronal nicotinic synapse differentiation that have emerged from these studies. We also discuss the molecular players that target nAChRs to the surface membrane and the interneuronal synapse.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Receptores Nicotínicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurobiol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos