[beta-Lactam antibiotics]. / Antibióticos betalactámicos.
Enferm Infecc Microbiol Clin
; 21(1): 42-55, 2003 Jan.
Article
em Es
| MEDLINE
| ID: mdl-12550043
ABSTRACT
Betalactams, which act by inhibiting the last phase of bacterial cell wall synthesis, constitute the largest family of antimicrobial agents and the most extensively used in current clinical practice. These drug have a slow bactericidal action that is relatively independent of plasma concentrations, little toxicity and a broad therapeutic margin. Their spectrum has increased over the years with the incorporation of new molecules having greater activity against gram-negative bacilli. Nevertheless, the progressive emergence of acquired resistance has limited the empirical use of betalactams and their efficacy in certain situations. Despite this problem, penicillin is still the treatment of choice for a large number of classic infections, cephalosporins are widely used in surgical prophylaxis and severe community-acquired infections, carbapenems are the choice for mixed nosocomial and multiresistant bacterial infections and betalactamase inhibitors permit the effective use of amino- and ureido-penicillins in highly significant infections.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antibacterianos
Limite:
Humans
Idioma:
Es
Revista:
Enferm Infecc Microbiol Clin
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article