[The enhancing effect of electroporation and iontophoresis on the permeation of insulin through human skin].
Yao Xue Xue Bao
; 37(8): 649-52, 2002 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-12567783
ABSTRACT
AIM:
To study the enhancing effect of electroporation and iontophoresis on the permeation of insulin through human cadaver skin in vitro.METHODS:
Using side by side two-chamber diffusion cells, the flux of insulin achieved with iontophoresis and electrophoration were compared.RESULTS:
The application of high-voltage pulse combined with iontophoresis resulted in higher flux transdermal permeation of insulin than either one technique alone (P < 0.05). Pulsing at a higher voltage increased the flux of insulin more dramatically than pulsing at a lower voltage (P < 0.01). The transdermal transport of insulin by 90 pulse of 500 V (exponential pulse generater, pulse time 20-24 ms, pulse frequency 3 pulse.min-1) followed by iontophoresis led to a quick input and a high steady flux.CONCLUSION:
Electroporation combined with iontophoresis can enhance the permeation of insulin significantly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Iontoforese
/
Eletroporação
/
Insulina
Limite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
China