Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28.
Transplantation
; 75(3): 418-20, 2003 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-12589169
ABSTRACT
The immunogenicity of human leukocyte antigen (HLA)-A2 versus HLA-A28 was analyzed by antibody production, cytotoxic T-lymphocyte (CTL) induction, and graft survival. We observed that an HLA-A2 mismatched child in HLA-A28 women leads to HLA-A2 specific antibodies in 32% of the women (n=31), whereas in the case of an HLA-A28 child and HLA-A2 women (n=30), no HLA-A28 specific antibodies were found ( P<0.002). Also, the CTL precursor frequencies were significantly lower against HLA-A28 compared with CTLp frequencies against HLA-A2 ( P=0.012). Finally, the kidney graft survival was slightly better in HLA-A2 positive recipients transplanted with HLA-A28 mismatches. We can conclude that single HLA-A28 mismatches are less immunogenic in HLA-A2 individuals compared with single HLA-A2 mismatches in HLA-A28 individuals, which is probably because the mismatched epitopes on the HLA-A2 molecule are unique epitopes, whereas the mismatched epitopes on HLA-A28 are shared by other HLA-A and HLA-B molecules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígeno HLA-A2
/
Transplante de Rim
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Rejeição de Enxerto
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Sobrevivência de Enxerto
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Epitopos
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Transplantation
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Holanda