Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients.
Oncogene
; 22(7): 1070-2, 2003 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-12592393
ABSTRACT
It has been shown that methylation of CpG dinucleotides located in the promoter region of TP53 is associated with low expression levels of this gene. We have analysed the methylation status of one CpG dinucleotide and of three CCWGG motifs, also located in the promoter region of the gene, in bone marrow samples obtained from patients with acute lymphoblastic leukemia (ALL). Eight out of 25 samples analysed showed methylation of either the CpG dinucleotide, the CCWGG motifs or both. Relative to nonmethylated leukemia samples, TP53 expression levels were decreased in all methylated samples in which TP53 expression could be measured. Methylation of CpG and CCWGG motifs in the promoter of TP53 could represent a novel mechanism leading to functional impairment of this tumor suppressor gene in ALL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Leucêmica da Expressão Gênica
/
Genes p53
/
Regiões Promotoras Genéticas
/
Ilhas de CpG
/
Metilação de DNA
/
Inativação Gênica
/
Elementos Silenciadores Transcricionais
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Oncogene
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Espanha