[Identification and classification of beta-lactamases in clinical isolates of bacteria].
Jpn J Antibiot
; 55 Suppl A: 29-41, 2002 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-12599527
ABSTRACT
Emergence of bacterial resistance has rendered ineffective a number of previously valuable antibiotic treatments and now threatens the effectiveness of others. beta-Lactam resistance is no longer predominantly a hospital-treated problem; it has now become an important issue in community medicine. More than 100-beta-lactamases have been identified and classified according to their structure, substrate specificity, and whether they are chromosomal or plasmid-mediated. beta-Lactamase production is rare among Gram-positive pathogens, important exceptions being Staphylococcus aureus and Enterococcus faecalis. By contrast, many Gram-negative pathogens are beta-lactamase-positive; inducible and/or hyper-productive strains are particularly challenging in the clinical setting. Surveillance programs have shown that, in general, beta-lactam resistance is on the increase, and that the plasmid-mediated beta-lactamase have developed rapidly over past decade such as ESBLs and carbapenemases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamases
Tipo de estudo:
Diagnostic_studies
Idioma:
Ja
Revista:
Jpn J Antibiot
Ano de publicação:
2002
Tipo de documento:
Article