Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases.
Org Lett
; 5(5): 737-40, 2003 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-12605503
ABSTRACT
Peptide vinyl sulfones were prepared from 2-chlorotrityl resin-bound phenolic amino vinyl sulfones in high yield and purity. This method enables the convenient synthesis of peptide vinyl sulfones having different amino acids at the P(1) position. It also allows efficient synthesis of vinyl sulfone-containing, activity-based probes of cysteine proteases used in a proteomic experiment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonas
/
Compostos de Vinila
/
Cisteína Endopeptidases
/
Inibidores de Cisteína Proteinase
Limite:
Animals
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2003
Tipo de documento:
Article