Mucosal ulcerations revealing primitive hypereosinophilic syndrome.
Eur J Dermatol
; 13(2): 207-8, 2003.
Article
em En
| MEDLINE
| ID: mdl-12695143
ABSTRACT
We report the case of a 27 year-old man developing recurrent oral aphtosis associated with fever and 8 kg of weight loss. Moderate splenomegaly was observed on physical examination and neurological and cardiac examination were normal. Laboratory findings included marked eosinophilia at 3280 giga/l. Bone marrow (BM) examination revealed a myeloproliferative syndrome with mature eosinophils. Splenectomy was performed because of a suspected nodule on the BM, the histopathology revealed a myeloid metaplasia. The diagnosis of myeloproliferative form of hypereosinophilic syndrome (HES) was made. He was treated with interferon-alfa and hydroxyurea. After two years of treatment he had no ulcer recurrence and eosinophil count was at 180 giga/l. Mucosal manifestations as a prodromal symptom of HES are rare. The histology of the lesions shows numerous eosinophils; immunohistochemical analysis confirms the presence of eosinophil peroxydase, major basic protein and eosinophil derived neurotoxin. A few cases have been described. Death occurs 11 months to 5 years after the diagnosis of oral ulcerations. The treatment consists of interferon-alfa and hydroxyurea.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estomatite Aftosa
/
Síndrome Hipereosinofílica
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França