Synthesis and anticancer activity of 5-diethylaminomethyl derivatives and nitrogen mustards of uracil and 2-thiouracils.
J Med Chem
; 19(5): 639-42, 1976 May.
Article
em En
| MEDLINE
| ID: mdl-1271405
ABSTRACT
Several 5-diethylaminomethyl derivatives and nitrogen mustards of uracil and 2-thiouracil have been synthesized and tested for their potential anticancer activity in vitro on KB cells and in vivo on Ehrlich carcinoma. Among the alkylating derivatives tested several showed cytotoxic activity in vitro and compound V [5-[bis(2-chloroethyl) amino] methyl-6-propyluracil hydrochloride] showed both in vitro and in vivo anticancer activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiouracila
/
Uracila
/
Antineoplásicos
/
Compostos de Mostarda Nitrogenada
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1976
Tipo de documento:
Article