[Acute myeloblastic leukemia without maturation (AML-M1) with basophilic elements and associated with translocation t(6;9)]. / Leucémie aiguë myéloblastique sans maturation (LAM1) avec éléments basophiles associée à la translocation t(6;9).
Ann Biol Clin (Paris)
; 61(3): 352-7, 2003.
Article
em Fr
| MEDLINE
| ID: mdl-12805015
ABSTRACT
The clinical, hematological, and cytogenetic data from a 4 year-old child with acute myeloid (AML-M1) and basophilia is reported. Interestingly, cytogenetic investigations revealed the presence of the translocation t(6;9) (p23;q34). This abnormality is rare and associated with myelodysplastic syndromes or with subtypes of acute myeloid leukemia (M1, M2, M4, M7), usually with preceding or underlying myelodysplasia. The prognosis is poor, without response to chemotherapy regimen alone. Allogeneic bone marrow transplantation appears likely to be a more appropriate treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Basófilos
/
Cromossomos Humanos Par 6
/
Cromossomos Humanos Par 9
/
Leucemia Mieloide Aguda
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Humans
/
Male
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
2003
Tipo de documento:
Article