Lower susceptibility of low density lipoprotein to in vitro oxidation in diabetic patients.
Biochem Int
; 28(5): 835-42, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1288493
ABSTRACT
The susceptibility to peroxidative stress of low density lipoprotein (LDL), induced by incubation with CuSO4, has been studied in eleven diabetic patients and eleven control subjects. Our results suggest that oxidized LDL (OX-LDL) of diabetic patients have a significant higher reactivity to 2,4,6-trinitrobenzene sulfonic acid (TNBS) than controls, that indicates a lower susceptibility of LDL to oxidative stress. Furthermore using the fluorescence polarization (Pf) of 1,6-diphenyl-1,3,5-hexatriene (DPH) and its phosphatidylcholine derivative (DPH-PC) we have shown that peroxidation induces a decrease of fluidity in OX-LDL of controls and diabetic patients, both at the lipoprotein surface, where is localized DPH-PC and at the interface between lipoprotein surface and core which is probed by DPH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxidação de Lipídeos
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
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Lipoproteínas LDL
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Biochem Int
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália