[Synthesis of modified oligosaccharides of the N-glycoprotein as substrate for N-acetylglucosaminyltransferase I]. / Synthese von modifizierten Oligosacchariden der N-Glycoproteine als Substrate für N-Acetylglucosaminyltransferase I.
Carbohydr Res
; 236: 39-71, 1992 Dec 15.
Article
em De
| MEDLINE
| ID: mdl-1291062
ABSTRACT
In the synthesis of modified derivatives of octyl O-(alpha-D-mannopyranosyl)-(1-->3)-O-[(alpha-D-mannopyranosyl)-(1-->6)]- beta-D-mannopyranoside, 4.,5-epoxypentyl, a 4-diazirinopentyl, and a 5-(iodoacetamido)pentyl group were attached to the 3''-OH of the trisaccharide. The diazirino derivative may be especially suitable for photolabeling of the active site of N-acetylglucosaminyltransferase I (GlcNAcT-I). In addition, the 2'-OH group of the above-mentioned trisaccharide was reduced to a 2'-deoxy group and substituted 2'-O-methyl group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Glicoproteínas
/
N-Acetilglucosaminiltransferases
Idioma:
De
Revista:
Carbohydr Res
Ano de publicação:
1992
Tipo de documento:
Article