MAOI activity of some novel series of substituted thiazol-2-yl-hydrazines.
Pharmazie
; 47(12): 902-10, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1293612
ABSTRACT
Three series of 2-thiazolylhydrazines were synthetized and evaluated for their MAO inhibitory (MAOI) activity, both by in vivo tests, to assay their influence on several MAOI activity-related parameters (the variation on blood pressure induced by tyramine and clonidine and L-amfetamine-induced hypermotility) and in vitro tests, to assay their effect on rat brain mitochondria by a kinuramine fluorimetric assay. In vivo, all the tested compounds significatively influenced the evaluative parameters used. As regards in vitro test, all compounds displayed MAOI activity at a concentration of 1.10(-4) mol.l-1, which was significant in several cases. In the discussion of the results, the influence of the structure on the biological activity of the prepared compounds was delineated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Encéfalo
/
Hidrazinas
/
Mitocôndrias
/
Inibidores da Monoaminoxidase
Limite:
Animals
Idioma:
En
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália