Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7.
J Exp Med
; 175(6): 1613-21, 1992 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-1316931
ABSTRACT
Mls-1 is an endogenous superantigen that leads to in vivo deletion and in vitro stimulation of T cell receptor (TCR) V beta 6-, 7-, 8.1-, and 9-expressing cells. The MA/MyJ mouse deletes the identical set of TCR from its mature T cell repertoire; however, it does not contain Mtv-7, the murine mammary tumor provirus (MMTV), whose sag gene encodes Mls-1. Interestingly, the superantigen activity of this mouse strain segregates with a new mammary tumor provirus, Mtv-43, not seen in other inbred strains. The predicted amino acid sequence of the sag gene of Mtv-43 was compared with that of Mtv-7. Strikingly, the COOH terminus of the two molecules is very similar, while all other MMTV-encoded superantigens differ 100% in this segment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores de Antígenos de Linfócitos T
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Linfócitos T
/
Provírus
/
Antígenos Secundários de Estimulação de Linfócitos
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Vírus do Tumor Mamário do Camundongo
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Genes Virais
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1992
Tipo de documento:
Article