Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate.
Eur J Surg Oncol
; 18(4): 373-8, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1325925
ABSTRACT
The Golden Syrian hamster, which has a bile acid profile similar to that of humans, is often used as an experimental model for cholangiocarcinoma. Unfortunately, most chemical carcinogens result in other tumour types also being induced which can be disadvantageous. In the present study, we describe the development of cholangiocarcinoma associated with precursor lesions of bile duct proliferation and dysplasia which occurred following a single i.v. dose of methylazoxymethyl acetate (10, 20 or 40 mg/kg body weight). Moreover, no other tumours were induced. This model may, therefore, prove useful in investigating the steps involved in the carcinogenesis of cholangiocarcinoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
/
Adenoma de Ducto Biliar
Limite:
Animals
Idioma:
En
Revista:
Eur J Surg Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Reino Unido