Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Science
; 257(5077): 1689-94, 1992 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-1388288
ABSTRACT
Human cyclin E, originally identified on the basis of its ability to function as a G1 cyclin in budding yeast, associated with a cell cycle-regulated protein kinase in human cells. The cyclin E-associated kinase activity peaked during G1, before the appearance of cyclin A, and was diminished during exit from the cell cycle after differentiation or serum withdrawal. The major cyclin E-associated kinase in human cells was Cdk2 (cyclin-dependent kinase 2). The abundance of the cyclin E protein and the cyclin E-Cdk2 complex was maximal in G1 cells. These results provide further evidence that in all eukaryotes assembly of a cyclin-Cdk complex is an important step in the biochemical pathway that controls cell proliferation during G1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Fase G1
/
Proteínas Serina-Treonina Quinases
/
Ciclinas
/
Quinases Ciclina-Dependentes
/
Quinases relacionadas a CDC2 e CDC28
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1992
Tipo de documento:
Article