A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.
J Neuroimmunol
; 143(1-2): 88-92, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14575921
ABSTRACT
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA from 200 patients and 200 controls. A total of 91 markers showed evidence of association. When compared to our in-house physical map of the genome, six 2-Mb regions containing at least two of these markers were detected. Of those, three regions have one or more markers among the 20 most strongly associated chromosomes 3q25, 6p21.3 (the MHC region) and 19q13.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Testes Genéticos
/
Repetições de Microssatélites
/
Esclerose Múltipla
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Islândia