A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.
Nature
; 425(6961): 917-25, 2003 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-14586460
ABSTRACT
The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biblioteca Gênica
/
Sistema Nervoso Central
/
Genes Reporter
/
Transgenes
/
Perfilação da Expressão Gênica
/
Cromossomos Artificiais Bacterianos
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos