Altered expression of nonclassical HLA class Ib antigens in human renal cell carcinoma and its association with impaired immune response.
Hum Immunol
; 64(11): 1081-92, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14602239
ABSTRACT
An optimal antitumoral immune response requires the activation of both CD8(+) and CD4(+) T lymphocytes by the peptide antigen presentation via the human leukocyte antigen (HLA) class I and class II molecules, respectively. Downregulation or loss of HLA molecules has been found in human renal cell carcinoma (RCC) and provides a strategy of these tumors to evade T-cell mediated immunosurveillance. In addition, a tumor-specific upregulation of HLA-G has been recently described in RCC, which also leads to an impaired immune response. We here summarize the frequency of the constitutive and/or interferon-gamma (IFN-gamma) inducible expression of nonclassical HLA class Ib antigens in RCC cell lines, surgically removed RCC lesions and normal kidney epithelium, the molecular characteristics of HLA-G expression, and its role in immune recognition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Antígenos de Histocompatibilidade Classe I
/
Antígenos HLA
/
Neoplasias Renais
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha